{"id":25356,"date":"2023-06-30T09:49:51","date_gmt":"2023-06-30T12:49:51","guid":{"rendered":"https:\/\/portaldasaudenews.com\/?p=25356"},"modified":"2023-06-30T09:49:51","modified_gmt":"2023-06-30T12:49:51","slug":"pesquisadores-depositam-patente-no-inpi-para-tratar-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/portaldasaudenews.com\/?p=25356","title":{"rendered":"Pesquisadores depositam patente no INPI para tratar c\u00e2ncer de mama"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Um grupo de dez pesquisadores das universidades Federal do Rio de Janeiro (UFRJ) e Federal Fluminense (UFF) depositou patente no Instituto Nacional de Propriedade Industrial (INPI) para tratamento contra o c\u00e2ncer de mama.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">O estudo descreve o desenvolvimento de um novo composto sint\u00e9tico direcionado \u00e0 prote\u00edna conhecida como p53 quando ela apresenta muta\u00e7\u00e3o. Os testes realizados apontaram para essa subst\u00e2ncia capaz de reverter a fun\u00e7\u00e3o da prote\u00edna mutada. A patente \u00e9 fruto de duas teses de doutorado da UFF e da UFRJ.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">O professor da Faculdade de Farm\u00e1cia da UFF, Vitor Ferreira, que integra o grupo de pesquisadores, explicou \u00e0 Ag\u00eancia Brasil que a prote\u00edna p53 \u201csupostamente\u201d deveria ser a guardi\u00e3 do genoma humano. O coordenador do Instituto Nacional de Ci\u00eancia e Tecnologia de Biologia Estrutural e Bioimagem (Inbeb) e professor da UFRJ, Jerson Lima, disse que essa prote\u00edna atua como protetora do DNA, suprimindo o aparecimento de tumores. Quando, por\u00e9m, ela sofre uma muta\u00e7\u00e3o dentro do organismo, perde sua fun\u00e7\u00e3o protetora e passa a estimular o crescimento do tumor e a torn\u00e1-lo mais resistente a drogas.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cEla passa a trabalhar contra e essa c\u00e9lula passa a ser uma c\u00e9lula tumoral\u201d, explicou Ferreira. \u201cEm mais de 90% das c\u00e9lulas tumorais, a prote\u00edna p53 sofre muta\u00e7\u00e3o e perde a fun\u00e7\u00e3o dela\u201d, sustentou. O tipo de tumor de mama usado na pesquisa pelo grupo \u00e9 chamado tumor negativo.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">A pesquisa recebeu financiamento de R$ 2 milh\u00f5es, divididos meio a meio entre a Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (Faperj) e o Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq). Um artigo de revis\u00e3o do trabalho foi publicado esta semana no peri\u00f3dico internacional Chemical Review.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cA gente acredita que essa subst\u00e2ncia \u00e9 a mais promissora de todas porque deu um efeito grande, inclusive reduzindo o tumor em animais e atuando, principalmente, na descoberta, que o nosso grupo foi pioneiro, que \u00e9 a capacidade de muta\u00e7\u00f5es da p53\u201d, afirmou Lima.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Os pesquisadores j\u00e1 est\u00e3o conversando com uma empresa farmac\u00eautica que estaria interessada em realizar os estudos cl\u00ednicos em humanos.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Essa etapa \u00e9 necess\u00e1ria e pode resultar na fabrica\u00e7\u00e3o do primeiro f\u00e1rmaco no Brasil para tratamento de c\u00e2ncer de mama, destacou Vitor Ferreira. Com as informa\u00e7\u00f5es da Ag\u00eancia Brasil.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>*Foto: Ilustra\u00e7\u00e3o<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Um grupo de dez pesquisadores das universidades Federal do Rio de Janeiro (UFRJ) e Federal<\/p>\n","protected":false},"author":1,"featured_media":22427,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[48,28],"tags":[],"class_list":["post-25356","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brasil","category-saude-brasil"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pesquisadores depositam patente no INPI para tratar c\u00e2ncer de mama - Portal da Sa\u00fade News<\/title>\n<meta name=\"description\" content=\"O estudo descreve o desenvolvimento de um novo composto sint\u00e9tico direcionado \u00e0 prote\u00edna conhecida como p53 quando ela apresenta muta\u00e7\u00e3o.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/portaldasaudenews.com\/?p=25356\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pesquisadores depositam patente no INPI para tratar c\u00e2ncer de mama - 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